Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

@article{Ellison2013AdultCC,
  title={Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair},
  author={Georgina M. Ellison and Carla Vicinanza and Andrew J. H. Smith and Iolanda Aquila and Angelo Leone and Cheryl D. Waring and Beverley J. Henning and Giuliano Giuseppe Stirparo and Roberto Papait and Marzia Scarf{\`o} and Valter Agosti and Giuseppe Viglietto and Gianluigi Condorelli and Ciro Indolfi and Sergio Ottolenghi and Daniele Torella and Bernardo Nadal-Ginard},
  journal={Cell},
  year={2013},
  volume={154},
  pages={827-842}
}
The epidemic of heart failure has stimulated interest in understanding cardiac regeneration. Evidence has been reported supporting regeneration via transplantation of multiple cell types, as well as replication of postmitotic cardiomyocytes. In addition, the adult myocardium harbors endogenous c-kit(pos) cardiac stem cells (eCSCs), whose relevance for regeneration is controversial. Here, using different rodent models of diffuse myocardial damage causing acute heart failure, we show that eCSCs… CONTINUE READING
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