Adult brain neurogenesis and psychiatry: a novel theory of depression

@article{Jacobs2000AdultBN,
  title={Adult brain neurogenesis and psychiatry: a novel theory of depression},
  author={Barry L. Jacobs and Henriette van Praag and Fred H. Gage},
  journal={Molecular Psychiatry},
  year={2000},
  volume={5},
  pages={262-269}
}
Neurogenesis (the birth of new neurons) continues postnatally and into adulthood in the brains of many animal species, including humans. This is particularly prominent in the dentate gyrus of the hippocampal formation. One of the factors that potently suppresses adult neurogenesis is stress, probably due to increased glucocorticoid release. Complementing this, we have recently found that increasing brain levels of serotonin enhance the basal rate of dentate gyrus neurogenesis. These and other… 
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