Adult-born hippocampal neurons mature into activity-dependent responsiveness.

  title={Adult-born hippocampal neurons mature into activity-dependent responsiveness.},
  author={Sebastian Jessberger and Gerd Kempermann},
  journal={The European journal of neuroscience},
  volume={18 10},
The mammalian hippocampus is a highly plastic brain structure in which new neurons are generated throughout adulthood. Do these new neurons qualitatively and quantitatively participate in the activity-dependent gene expression after challenging the hippocampus in a learning task? Adult mice were injected with bromodeoxyuridine (BrdU) to label dividing cells and indeed, individual BrdU-labelled new neurons expressed the immediate early gene protein (IEGp) c-fos during the acquisition phase of… CONTINUE READING
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