Adult and paediatric patients with minimal change nephrotic syndrome show no major alterations in glomerular expression of sulphated heparan sulphate domains.

@article{Wijnhoven2007AdultAP,
  title={Adult and paediatric patients with minimal change nephrotic syndrome show no major alterations in glomerular expression of sulphated heparan sulphate domains.},
  author={Tessa J. M. Wijnhoven and J. M. van Geelen and Marinka A. H. Bakker and Joost F. M. Lensen and Angelique L.W.M.M. Rops and Andrea Brechtsje Kramer and Gerjan Navis and Mabel J W van den Hoven and Johan van der Vlag and Jo H. M. Berden and Jack F. M. Wetzels and Lambert P W Van den Heuvel and Leo Monnens and Toin H van Kuppevelt},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2007},
  volume={22 10},
  pages={
          2886-93
        }
}
BACKGROUND Minimal change nephrotic syndrome (MCNS) is the most frequent form of nephrotic syndrome in childhood. In the glomerular basement membrane (GBM) of adult patients with MCNS, a reduced expression of a specific heparan sulphate (HS) domain has been reported. In children with MCNS, urinary activity of the HS-degrading enzyme heparanase was increased. It is, therefore, possible that a decreased GBM HS expression is associated with the pathogenesis of proteinuria in patients with MCNS… CONTINUE READING

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