Adult and neonatal anti‐Gal response in knock‐out mice for α1,3galactosyltransferase

@article{LaTemple1998AdultAN,
  title={Adult and neonatal anti‐Gal response in knock‐out mice for α1,3galactosyltransferase},
  author={D. LaTemple and U. Galili},
  journal={Xenotransplantation},
  year={1998},
  volume={5}
}
ABSTRACT: The knockout mouse to αl,3galactosyltransferase (αl,3GT KO) lacks the ability to synthesize α‐gal epitopes (Galα1,3Galβ1,4GlcNAc‐R) and is capable of producing low amounts of the natural anti‐Gal antibody. The present study indicates that repeated immunization of these mice with rabbit red blood cell (RRBC) membranes results in production of anti‐Gal in titers and specificity similar to those in humans. In contrast, immunized wild‐type mice completely lack anti‐Gal. Anti‐Gal in the α1… Expand
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