Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes.

@article{Ikeda1999AdultTL,
  title={Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes.},
  author={Katsuhisa Ikeda and Mikio Oka and Yoko Yamada and Hiroshi Soda and Minoru Fukuda and Anna Kinoshita and Kazuki Tsukamoto and Yuji Noguchi and Hiroharu Isomoto and Fuminao Takeshima and Kunihiko Murase and Shimeru Kamihira and Masao Tomonaga and Shigeru Kohno},
  journal={International journal of cancer},
  year={1999},
  volume={82 4},
  pages={599-604}
}
Adult T-cell leukemia (ATL) is a T-cell malignancy caused by human T-cell-leukemia-virus-I (HTLV-I) infection. ATL comprises 4 clinical forms: acute, chronic, smoldering and lymphoma types. ATL is usually resistant to conventional chemotherapy and has a relatively poor prognosis; however, the resistance mechanisms remain undetermined. To explore the multidrug-resistance (MDR) mechanisms of ATL, we examined the expression and functional activity of MDR-related genes in peripheral-blood… CONTINUE READING