Adult Stem Cell Driven Genesis of Human-Shaped Articular Condyle

  title={Adult Stem Cell Driven Genesis of Human-Shaped Articular Condyle},
  author={Adel Alhadlaq and Jennifer H Elisseeff and Liu Hong and Christopher G. Williams and Arnold I Caplan and Blanka Sharma and Ross A. Kopher and Sara Tomkoria and Donald P. Lennon and Aurora Santos Lopez and Jeremy J Mao},
  journal={Annals of Biomedical Engineering},
Uniform design of synovial articulations across mammalian species is challenged by their common susceptibility to joint degeneration. The present study was designed to investigate the possibility of creating human-shaped articular condyles by rat bone marrow-derived mesenchymal stem cells (MSCs) encapsulated in a biocompatible poly(ethylene glycol)-based hydrogel. Rat MSCs were harvested, expanded in culture, and treated with either chondrogenic or osteogenic supplements. Rat MSC-derived… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 67 extracted citations


Publications referenced by this paper.
Showing 1-10 of 61 references

Formation of a mandibular condyle in vitro by tissue engineering

  • C. S. Ahmad, Z. A. Cohen, W. N. Levine, G. A. Ateshian, V. C. Mow
  • J Oral Maxillofac . Surg .
  • 2003

Bone destruction in arthritis

  • A. J. Grodzinsky, M. E. Levenston, M. Jin, E. H. Frank
  • Ann . Rheum . Dis .
  • 2002

Similar Papers

Loading similar papers…