Adsorptive-mediated brain delivery systems.

  title={Adsorptive-mediated brain delivery systems.},
  author={Wei Lu},
  journal={Current pharmaceutical biotechnology},
  volume={13 12},
  • Wei Lu
  • Published 2012 in Current pharmaceutical biotechnology
The blood-brain barrier (BBB), which impedes drug penetration into the central nervous system, is composed of specific structures formed by brain capillary endothelial cells and sheathed by astrocytic end-feet through basement membrane. Many brain drug delivery strategies have focused on adsorptive-mediated transcytosis (AMT), which is triggered by electrostatic interaction between cationic molecules and anionic microdomains on the cytoplasm membrane of the brain capillary endothelial cells… CONTINUE READING