Adsorptive endocytosis of California encephalitis virus into mosquito and mammalian cells: a role for G1.

@article{Hacker1997AdsorptiveEO,
  title={Adsorptive endocytosis of California encephalitis virus into mosquito and mammalian cells: a role for G1.},
  author={Jill K. Hacker and James L. Hardy},
  journal={Virology},
  year={1997},
  volume={235 1},
  pages={40-7}
}
The G1 glycoprotein of California encephalitis (CE) virus plays a critical role in the infection of mosquito and mammalian cells. We found that CE virus enters baby hamster kidney (BHK-21) and Aedes albopictus (C6/36) cells by the endocytic pathway. Ammonium chloride, a lysosomotropic amine that prevents release of virus from endosomes, inhibited infection of both cell types when added within 10 min after viral adsorption. In addition, infected cells formed polykaryons when the extracellular pH… CONTINUE READING

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