Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface.

  title={Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface.},
  author={Holger Grohganz and Matthias Dr Rischer and Martin Brandl},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={21 2-3},
  • H. Grohganz, M. Rischer, M. Brandl
  • Published 1 February 2004
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
High performance liquid chromatography (HPLC) analysis of increasing amounts of the decapeptide Cetrorelix, a potent antagonist of the luteinising hormone-releasing hormone, in distilled water resulted in a poor and variable response when solutions of low concentration (0.2-4microg/ml) were analysed. Rinsing experiments revealed loss of analyte due to adsorption to the vial surfaces as the main reason for this. The adsorption of Cetrorelix was found to follow a Langmuir isotherm reaching a… 
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    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2005
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