Adsorption of poly(ethylene glycol)-modified lysozyme to silica.

@article{Daly2005AdsorptionOP,
  title={Adsorption of poly(ethylene glycol)-modified lysozyme to silica.},
  author={Susan M Daly and Todd M. Przybycien and Robert D Tilton},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2005},
  volume={21 4},
  pages={1328-37}
}
Covalent grafting of poly(ethylene glycol) (PEG) to pharmaceutical proteins, "PEGylation", is becoming more commonplace due to improved therapeutic efficacy. As these conjugates encounter interfaces in manufacture, purification, and end use and adsorption to these interfaces may alter achievable production yields and in vivo efficacies, it is important to understand how PEGylation affects protein adsorption mechanisms. To this end, we have studied the adsorption of unmodified and PEGylated… CONTINUE READING