Adsorption of pepsin by aluminum hydroxide I: Adsorption mechanism.

  title={Adsorption of pepsin by aluminum hydroxide I: Adsorption mechanism.},
  author={R J Sepelyak and Joachim Feldkamp and T E Moody and Joe L. White and Stanley L. Hem},
  journal={Journal of pharmaceutical sciences},
  volume={73 11},
Adsorption of pepsin by gibbsite and boehmite, non-acid-reactive forms of aluminum hydroxide, was observed and related to the surface area of the adsorbent. Adsorption was pH dependent, with maximum adsorption occurring between pH 2.7-3.3 for gibbsite and pH 2.7-4.3 for boehmite. Electrostatic attraction was an important adsorption mechanism at the pH conditions encountered in the GI tract; the isoelectric point of pepsin was approximately 1, giving it a negative charge, and the point of zero… CONTINUE READING