Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake

@article{Chavany1994AdsorptionOO,
  title={Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake},
  author={Christine Chavany and Tula Saison-Behmoaras and Trung Le Doan and Francis Puisieux and Patrick Couvreur and Claude H{\'e}l{\`e}ne},
  journal={Pharmaceutical Research},
  year={1994},
  volume={11},
  pages={1370-1378}
}
Oligonucleotides can be adsorbed on polyisohexylcyanoacrylate nanoparticles in the presence of hydrophobic quartenary ammonium salts. Oligonucleotides bound to nanoparticles are protected from nuclease attack both in buffer and in cell culture media. Cellular uptake of Oligonucleotides is increased when they are adsorbed onto nanoparticles as a result of the capture of nanoparticles by an endocytic/phagocytic pathway. Intracellular stability towards nucleolytic degradation is increased in the… CONTINUE READING

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