Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model.

@article{Mortell2004AdriamycinIN,
  title={Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model.},
  author={A. Mortell and A. O'donnell and S. Giles and J. Bannigan and P. Puri},
  journal={Journal of pediatric surgery},
  year={2004},
  volume={39 6},
  pages={
          859-63
        }
}
BACKGROUND/PURPOSE The Adriamycin rat model (ARM) is a well-established model of the Vertebral, Anorectal, Cardiac, Tracheoesophageal, Renal, Limb (VACTERL) association. The notochord, which expresses Sonic Hedgehog (Shh), has been found to be grossly malformed with ventral ectopic branches in the foregut region of embryos in the ARM. The authors designed this study to test the hypothesis that Shh-expressing ectopic notochord could contribute to an increased volume of notochord relative to… Expand
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