Adriamycin induces H2AX phosphorylation in human spermatozoa.


AIM To investigate whether adriamycin induces DNA damage and the formation of gammaH2AX (the phosphorylated form of histone H2AX) foci in mature spermatozoa. METHODS Human spermatozoa were treated with adriamycin at different concentrations. gammaH2AX was analyzed by immunofluorescent staining and flow cytometry and double-strand breaks (DSB) were… (More)
DOI: 10.1111/j.1745-7262.2008.00400.x

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