Adriamycin-induced oxidative stress, activation of MAP kinases and apoptosis in isolated cardiomyocytes.

@article{Lou2006AdriamycininducedOS,
  title={Adriamycin-induced oxidative stress, activation of MAP kinases and apoptosis in isolated cardiomyocytes.},
  author={Huiquan Lou and Kuljeet Kaur and Anita K. Sharma and Pawan K. Singal},
  journal={Pathophysiology : the official journal of the International Society for Pathophysiology},
  year={2006},
  volume={13 2},
  pages={103-9}
}
BACKGROUND Adriamycin (ADR) induced heart failure is associated with an increase in oxidative stress and apoptosis. Changes due to ADR in mitogen-activated protein kinases (ERK1/2 and p38 MAPKs), pro- and anti-apoptotic proteins (Bax and Bcl-xl) and apoptosis were examined in isolated adult rat cardiomyocytes. METHODS Isolated adult rat cardiomyocytes… CONTINUE READING