Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis

  title={Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis},
  author={Kendall B. Wallace},
  journal={Cardiovascular Toxicology},
Adriamycin (doxorubicin) is a potent and broad-spectrum antineoplastic agent, the clinical utility of which is limited by the development of a cumulative and irreversible cardiomyopathy. Although the drug affects numerous structures in different cell types, the mitochondrion appears to a principal subcellular target for the development of cardiomyopathy. This review describes evidence demonstrating that adriamycin redox cycles on complex I of the mitochondrial electron transport chain to… CONTINUE READING