Adriamycin-induced changes of creatine kinase activity in vivo and in cardiomyocyte culture.

  title={Adriamycin-induced changes of creatine kinase activity in vivo and in cardiomyocyte culture.},
  author={S M DeAtley and Michael Y. Aksenov and Marina V. Aksenova and Brad Jordan and John M. Carney and David Butterfield},
  volume={134 1},
Adriamycin (ADM) is an anthracycline anti-neoplastic agent, whose clinical effectiveness is limited by severe side effects, including cardiotoxicity. The toxic effects of ADM are likely to be the consequence of the generation of free radicals. This study demonstrates that ADM induces significant changes in the activity of the oxidative sensitive enzyme creatine kinase (CK) in the heart in vivo and in a cardiomyocyte culture model. The changes observed are likely to reflect the ability of ADM to… CONTINUE READING


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Publications referenced by this paper.
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Role of oxygen radical formation in anthracycline cardiac toxicity

  • J. H. Doroshow, G. Y. Locker
  • 1982
Highly Influential
5 Excerpts

Protein oxidation processes in aging brain

  • D. A. Butterfield, E. R. Stadtman
  • 1997
1 Excerpt

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