• Corpus ID: 15230770

Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity.

  title={Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity.},
  author={Jitbanjong Tangpong and Marsha P Cole and Rukhsana Sultana and Gururaj Joshi and Steven Estus and Mary Vore and William H. St. Clair and Suvina Ratanachaiyavong and Daret K. St. Clair and David Allan Butterfield},
  journal={Neurobiology of disease},
  volume={23 1},
The clinical effectiveness of adriamycin (ADR), a potent chemotherapeutic, is known to be limited by severe cardiotoxic side effects. However, the effect of ADR on brain tissue is not well understood. It is generally thought that ADR is not toxic to the brain because ADR does not pass the blood-brain barrier. The present study demonstrates that ADR autofluorescence was detected only in areas of the brain located outside the blood-brain barrier, but a strong tumor necrosis factor (TNF) alpha… 

Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

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