• Corpus ID: 15230770

Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity.

@article{Tangpong2006AdriamycininducedTC,
  title={Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity.},
  author={Jitbanjong Tangpong and Marsha P Cole and Rukhsana Sultana and Gururaj Joshi and Steven Estus and Mary Vore and William H. St. Clair and Suvina Ratanachaiyavong and Daret K. St. Clair and David Allan Butterfield},
  journal={Neurobiology of disease},
  year={2006},
  volume={23 1},
  pages={
          127-39
        }
}
The clinical effectiveness of adriamycin (ADR), a potent chemotherapeutic, is known to be limited by severe cardiotoxic side effects. However, the effect of ADR on brain tissue is not well understood. It is generally thought that ADR is not toxic to the brain because ADR does not pass the blood-brain barrier. The present study demonstrates that ADR autofluorescence was detected only in areas of the brain located outside the blood-brain barrier, but a strong tumor necrosis factor (TNF) alpha… 

Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

TLDR
It is demonstrated that treatment with ADR led to an increased circulating level of tumor necrosis factor‐alpha in wild‐type mice and in mice deficient in the inducible form of nitric oxide (iNOSKO), and it is suggested that NO is an important mediator, coupling the effect of ADR with cytokine production and subsequent activation of iNOS expression.

Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments

TLDR
The data demonstrate that ADR treatment elevates CNS inflammation that is linked to cognitive dysfunction and that attenuation of neuroinflammation reverses the adverse neurocognitive effects of chemotherapy.

Glutathione elevation by γ‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain

TLDR
This study test the hypothesis that, by elevating brain levels of GSH, the brain would be protected against oxidative stress in ADR‐injected mice, and results are discussed with regard to potential pharmacological prevention of brain cognitive dysfunction in patients receiving ADR chemotherapy.

Chemotherapy-Induced Cognitive Impairment Is Associated with Cytokine Dysregulation and Disruptions in Neuroplasticity

TLDR
Results indicate that chemobrain is associated with cytokine dysregulation and disrupted neuroplasticity of the brain.

Ginsenoside Rg1 Prevents Chemotherapy-Induced Cognitive Impairment: Associations with Microglia-Mediated Cytokines, Neuroinflammation, and Neuroplasticity

TLDR
Results indicate that Rg1 exerts its anti-chemobrain effect in an association with the inhibition of neuroinflammation by modulating microglia-mediated cytokines and the related upstream mediators, protecting neuronal activity and promoting neuroplasticity in particular brain regions associated with cognition processing.
...

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