Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells.

@article{Berczi1993AdriamycinCO,
  title={Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells.},
  author={Andrew Berczi and Kl{\'a}ra Barab{\'a}s and J A Sizensky and W. Page Faulk},
  journal={Archives of biochemistry and biophysics},
  year={1993},
  volume={300 1},
  pages={356-63}
}
Adriamycin (ADR) was coupled to human transferrin (TRF) by using a glutaraldehyde crosslinking method. The TRF-ADR conjugates were separated by column chromatography and the molar ratio of ADR to TRF (i.e., conjugation number) for the studied conjugates was found to be 1.2. Analysis in sodium dodecyl sulfate-polyacrylamide gels demonstrated that TRF-ADR conjugates with this molar ratio had the same mobility as native TRF and contained few aggregates. The ADR remained conjugated to TRF under… CONTINUE READING
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