Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.

@article{Henderson1978AdriamycinAD,
  title={Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.},
  author={Charles A. Henderson and E N Metz and Stanley P. Balcerzak and Arthur L. Sagone},
  journal={Blood},
  year={1978},
  volume={52 5},
  pages={878-85}
}
Adriamycin and daunomycin produce dose-related cardiac toxicity that may be related to oxygen radicals. Addition of these compounds to human erythrocyte suspensions resulted in stimulation of hexose monophosphate shunt activity that was markedly impaired in the absence of oxyhemoglobin. Evidence for generation of hydrogen peroxide by these compounds was provided by oxidation of reduced glutathione, by 14C-formate oxidation, and by the catalase-aminotriazole trapping technique. These experiments… CONTINUE READING
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Altered myocardial glutathione levels : A possible mechanism of Adriamycin toxicity

  • RD Olson, McDonald iS, +4 authors JA Oaten
  • Fed Proc
  • 1977

Gluta - thione peroxidase : Its role in Adriamycin cardiotoxicity

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