Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

@article{Tangpong2007AdriamycinmediatedNO,
  title={Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain},
  author={J. Tangpong and M. Cole and R. Sultana and S. Estus and M. Vore and W. S. St Clair and S. Ratanachaiyavong and D. S. St. Clair and D. Butterfield},
  journal={Journal of Neurochemistry},
  year={2007},
  volume={100}
}
  • J. Tangpong, M. Cole, +6 authors D. Butterfield
  • Published 2007
  • Biology, Medicine
  • Journal of Neurochemistry
  • Adriamycin (ADR), a potent anti‐tumor agent, produces reactive oxygen species (ROS) in cardiac tissue. Treatment with ADR is dose‐limited by cardiotoxicity. However, the effect of ADR in the other tissues, including the brain, is unclear because ADR does not pass the blood–brain barrier. Some cancer patients receiving ADR treatment develop a transient memory loss, inability to handle complex tasks etc., often referred to by patients as chemobrain. We previously demonstrated that ADR causes CNS… CONTINUE READING
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    References

    SHOWING 1-10 OF 92 REFERENCES
    Adriamycin-induced, TNF-α-mediated central nervous system toxicity
    • 141
    Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity.
    • 82
    • PDF
    Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain
    • 150
    • PDF
    Oxidative Damage Precedes Nitrative Damage in Adriamycin-Induced Cardiac Mitochondrial Injury
    • 90
    • PDF
    The Use of Transgenic and Mutant Mice to Study Oxygen Free Radical Metabolism
    • 105
    Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity
    • 266
    • PDF