Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

@article{Tangpong2007AdriamycinmediatedNO,
  title={Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain},
  author={J. Tangpong and M. Cole and R. Sultana and S. Estus and M. Vore and W. S. St Clair and S. Ratanachaiyavong and D. S. St. Clair and D. Butterfield},
  journal={Journal of Neurochemistry},
  year={2007},
  volume={100}
}
  • J. Tangpong, M. Cole, +6 authors D. Butterfield
  • Published 2007
  • Biology, Medicine
  • Journal of Neurochemistry
    • Adriamycin (ADR), a potent anti‐tumor agent, produces reactive oxygen species (ROS) in cardiac tissue. Treatment with ADR is dose‐limited by cardiotoxicity. However, the effect of ADR in the other tissues, including the brain, is unclear because ADR does not pass the blood–brain barrier. Some cancer patients receiving ADR treatment develop a transient memory loss, inability to handle complex tasks etc., often referred to by patients as chemobrain. We previously demonstrated that ADR causes CNS… CONTINUE READING
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