Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain

@article{Tangpong2007AdriamycinmediatedNO,
  title={Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain},
  author={Jitbanjong Tangpong and Marsha P Cole and Rukhsana Sultana and Steven Estus and Mary Vore and William H. St. Clair and Suvina Ratanachaiyavong and Daret K. St. Clair and David Allan Butterfield},
  journal={Journal of Neurochemistry},
  year={2007},
  volume={100}
}
Adriamycin (ADR), a potent anti‐tumor agent, produces reactive oxygen species (ROS) in cardiac tissue. Treatment with ADR is dose‐limited by cardiotoxicity. However, the effect of ADR in the other tissues, including the brain, is unclear because ADR does not pass the blood–brain barrier. Some cancer patients receiving ADR treatment develop a transient memory loss, inability to handle complex tasks etc., often referred to by patients as chemobrain. We previously demonstrated that ADR causes CNS… 
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