Adrenomedullin stimulates proline-rich tyrosine kinase 2 in vascular smooth muscle cells.

@article{Iwasaki2001AdrenomedullinSP,
  title={Adrenomedullin stimulates proline-rich tyrosine kinase 2 in vascular smooth muscle cells.},
  author={Hiroshi Iwasaki and Masayoshi Shichiri and Fumiaki Marumo and Yukio Hirata},
  journal={Endocrinology},
  year={2001},
  volume={142 2},
  pages={564-72}
}
A novel vasodilator peptide, adrenomedullin (AM) stimulates extracellular signal-regulated kinase (ERK) 1/2 via yet uncharacterized 120 kDa tyrosine kinase(s) in rat vascular smooth muscle cells (VSMC). In the present study, we have examined whether the AM-activated tyrosine kinase is proline-rich tyrosine kinase 2 (PYK2) associable with adapter proteins. AM rapidly (within 30 sec) and dose dependently increased tyrosine kinase activity, whose effect was enhanced in the presence of o-vanadate… CONTINUE READING
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