Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo

@article{Dunworth2008AdrenomedullinST,
  title={Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo},
  author={William P. Dunworth and Kimberly L Fritz-Six and Kathleen M Caron},
  journal={Peptides},
  year={2008},
  volume={29},
  pages={2243-2249}
}
The lymphatic vascular system functions to maintain fluid homeostasis by removing fluid from the interstitial space and returning it to venous circulation. This process is dependent upon the maintenance and modulation of a semi-permeable barrier between lymphatic endothelial cells of the lymphatic capillaries. However, our understanding of the lymphatic endothelial barrier and the molecular mechanisms that govern its function remains limited. Adrenomedullin (AM) is a 52 amino acid secreted… CONTINUE READING

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