Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock

@article{TemmesfeldWollbrueck2007AdrenomedullinRV,
  title={Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock},
  author={Bettina Temmesfeld-Wollbrueck and Bernhard Brell and Istv{\'a}n D{\'a}vid and Martin Dorenberg and J{\"o}rn Adolphs and Bernd T Schmeck and Norbert Suttorp and Stefan Hippenstiel},
  journal={Intensive Care Medicine},
  year={2007},
  volume={33},
  pages={703-710}
}
Current therapies of sepsis and septic shock require administration of a large volume of fluid to maintain hemodynamic stability. The vasoregulatory peptide adrenomedullin has been shown to prevent the transition to the fatal hypocirculatory septic state by poorly understood mechanisms. We tested the hypothesis that therapeutic administration of adrenomedullin would reduce vascular hyperpermeability, thereby contributing to improved hemodynamics and survival. Prospective randomized controlled… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Genes and sepsis: how tight is the fit?

Critical care medicine • 2008
View 17 Excerpts
Highly Influenced

What do families know? A question of interpretation.

Critical care medicine • 2008
View 17 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2004
View 1 Excerpt

Similar Papers

Loading similar papers…