Adrenomedullin receptor binding sites in rat brain and peripheral tissues.

@article{Juaneda2003AdrenomedullinRB,
  title={Adrenomedullin receptor binding sites in rat brain and peripheral tissues.},
  author={Christian Juaneda and Yvan Dumont and Jean Guy Chabot and Alain Fournier and R{\'e}mi Quirion},
  journal={European journal of pharmacology},
  year={2003},
  volume={474 2-3},
  pages={165-74}
}
The existence of specific adrenomedullin receptor binding sites was investigated using the agonist peptide fragment [125I]human adrenomedullin-(13-52) in rat brain, lung and vas deferens homogenates. Saturation-binding experiments suggest that [125I]human adrenomedullin-(13-52) binds to an apparent single population of sites with similar affinities (K(D) of 0.3 to 0.6 nM) but with different maximal binding capacity in the rat brain, lung and vas deferens homogenates (B(max) of 73, 1760 and 144… CONTINUE READING

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