Adrenomedullin microinjection into the area postrema increases blood pressure.

  title={Adrenomedullin microinjection into the area postrema increases blood pressure.},
  author={Marque A Allen and Pauline M. Smith and Alistair Ferguson},
  journal={The American journal of physiology},
  volume={272 6 Pt 2},
Adrenomedullin (ADM) circulates in the blood at concentrations comparable to other vasoactive peptides with established roles in cardiovascular regulation. Intravenously administered ADM produces a clear hypotensive effect, whereas intracerebroventricular microinjections result in increases in blood pressure (BP). Recently, we demonstrated that ADM influences neurons of the area postrema (AP), a central nervous system site implicated in cardiovascular control. However, to address directly the… CONTINUE READING


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