Adrenomedullin mediates vasodilation via CGRP1 receptors.

@article{Entzeroth1994AdrenomedullinMV,
  title={Adrenomedullin mediates vasodilation via CGRP1 receptors.},
  author={Michael Dr. Dipl.-Chem. Entzeroth and Henri N. Doods and Heike A. Wieland and Wolfgang Wienen},
  journal={Life sciences},
  year={1994},
  volume={56 1},
  pages={
          PL19-25
        }
}
Adrenomedullin is a recently discovered 52 amino acid polypeptide with potent hypotensive activity. The peptide possesses 21% homology with the amino acid sequence of human calcitonin gene-related peptide-alpha (hCGRP-alpha). In 125I-hCGRP-alpha receptor binding experiments using membranes from human neuroblastoma cells (SK-N-MC) adrenomedullin is a potent competitor with a Ki of 0.37 nM. In SK-N-MC cells hCGRP-alpha and adrenomedullin concentration-dependently increase cAMP levels with… CONTINUE READING

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Effect of aging on the expression of adrenomedullin and its receptor component proteins in the male reproductive system of the rat.

  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2007
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