Adrenomedullin mediates coronary vasodilation through adenosine receptors and KATP channels.

@article{Sabates1997AdrenomedullinMC,
  title={Adrenomedullin mediates coronary vasodilation through adenosine receptors and KATP channels.},
  author={B L Sabates and John D. Pigott and Ella U Choe and Martin Paspe Cruz and Howard L Lippton and Albert L Hyman and Lewis M. Flint and John Ferrara},
  journal={The Journal of surgical research},
  year={1997},
  volume={67 2},
  pages={163-8}
}
The following experiments were conducted to determine whether, and the mechanisms through which, endogenous peptides alter coronary artery blood flow. Ultrasonic transit time probes were placed around the ascending aorta and left anterior descending coronary artery in groups of anesthetized, open-chest dogs. A Millar pressure catheter monitored left ventricular developed pressure. Intracoronary artery bolus injections of adenosine (a purinergic receptor activator), pinacidil (a KATP channel… CONTINUE READING
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