Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo.

  title={Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo.},
  author={Jillian Cornish and Karen E. Callon and D. H. Coy. E. J. Coy and Naomi Y. Jiang and Liqun Xiao and G. J. Cooper and Ian R Reid},
  journal={The American journal of physiology},
  volume={273 6 Pt 1},
Adrenomedullin is a 52-amino acid vasodilator peptide produced in many tissues, including bone. It has 20% sequence identity with amylin, a regulator of osteoblast growth, and circulates in picomolar concentrations. The present study assesses whether adrenomedullin also acts on osteoblasts. At concentrations of 10(-12) M and greater, adrenomedullin produced a dose-dependent increase in cell number and [3H]thymidine incorporation in cultures of fetal rat osteoblasts. This effect was also seen… CONTINUE READING


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