Adrenomedullin is a potent inhibitor of angiotensin II-induced migration of human coronary artery smooth muscle cells.

@article{Kohno1997AdrenomedullinIA,
  title={Adrenomedullin is a potent inhibitor of angiotensin II-induced migration of human coronary artery smooth muscle cells.},
  author={Masashi Kohno and Koji Yokokawa and Hatsuyo Kano and Kenichi Yasunari and Mieko Minami and Takao Hanehira and Junichi Yoshikawa},
  journal={Hypertension},
  year={1997},
  volume={29 6},
  pages={1309-13}
}
The migration of coronary artery medial smooth muscle cells (SMCs) into the intima is proposed to be an important process of intimal thickening in coronary atherosclerotic lesions. In the current study, we examined the possible interaction of adrenomedullin, a novel vasorelaxant peptide, and angiotensin II (Ang II) on human coronary artery SMC migration using Boyden's chamber method. Ang II stimulated SMC migration in a concentration-dependent manner between 10(6) and 10(8) mol/L. This… CONTINUE READING

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