Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism.

@article{Abasolo2004AdrenomedullinIP,
  title={Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism.},
  author={Ibane Abasolo and Zhou Cheng Wang and Luis M. Montuenga and A. M. Rochas Calvo},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={322 3},
  pages={
          878-86
        }
}
Adrenomedullin (AM) is a multifunctional peptide expressed in the normal and malignant prostate, and in prostate cancer cells. To elucidate the potential role of AM in prostate cancer, we have transfected the human AM gene into PC-3, DU 145, and LNCaP prostate cancer cells. Northern blot, Western blot, and radioimmunoassay techniques confirmed an increase in the synthesis and secretion of the 6kDa mature peptide, in the AM-transfected clones. Proliferation and cell cycle assays demonstrated… CONTINUE READING
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Adrenomedullin prevents apoptosis in prostate cancer cells

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