Adrenomedullin inhibits angiotensin II-induced contraction in human aortic smooth muscle cells.

@article{Rossi2006AdrenomedullinIA,
  title={Adrenomedullin inhibits angiotensin II-induced contraction in human aortic smooth muscle cells.},
  author={Fabio M.V. Rossi and Catia Zappa and Antonella Ferraresi and Vittorio Santiemma},
  journal={Regulatory peptides},
  year={2006},
  volume={133 1-3},
  pages={155-9}
}
The vasodilating peptide adrenomedullin (AM) has been reported to regulate vascular tone as well as proliferation and differentiation of various cell types in an autocrine/paracrine manner. Our study was designed to investigate the effect of AM on Ang II-induced contraction on human aortic smooth muscle cells (HASMC) in vitro, evaluating the signal pathways involved. Our findings indicate that AM was able to inhibit HASMC Ang II-induced contraction (IC50 19 nM). AM stimulated cAMP production in… CONTINUE READING