Adrenomedullin inhibits angiotensin AT1A receptor expression and function in cardiac fibroblasts.

@article{Autelitano2003AdrenomedullinIA,
  title={Adrenomedullin inhibits angiotensin AT1A receptor expression and function in cardiac fibroblasts.},
  author={Dominic J. Autelitano and Rebecca Ridings and Luisa Pipolo and Walter Glen Thomas},
  journal={Regulatory peptides},
  year={2003},
  volume={112 1-3},
  pages={131-7}
}
Adrenomedullin (AM) is a multifunctional peptide hormone with wide-ranging actions related to cardiovascular homeostasis. AM receptors are highly expressed in the heart and AM has antihypertrophic and antiproliferative effects on cardiac myocytes and fibroblasts, respectively. We have investigated the interaction between AM and angiotensin II (Ang II) signalling in neonatal cardiac fibroblast cultures to determine whether the antagonistic effects of AM are mediated via the modulation of Ang II… CONTINUE READING

Similar Papers

Loading similar papers…