Adrenomedullin in cultured human retinal pigment epithelial cells.

  title={Adrenomedullin in cultured human retinal pigment epithelial cells.},
  author={Tetsuo Udono and Kyoichi Takahashi and Mauro Nakayama and Osamu Murakami and Yusuf K. Durlu and Minori Tamai and Shinobu Shibahara},
  journal={Investigative ophthalmology & visual science},
  volume={41 7},
PURPOSE To determine whether adrenomedullin (ADM), a vasorelaxant peptide is produced and secreted by human retinal pigment epithelial (RPE) cells, whether ADM expression is regulated by inflammatory cytokines and a growth factor, and whether ADM has proliferative effects on these cells. METHODS Production and secretion of ADM by cultured human RPE cells were examined by Northern blot analysis and radioimmunoassay. Regulation of the ADM expression by basic fibroblast growth factor, interferon… CONTINUE READING
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