Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP.

  title={Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP.},
  author={Supriya Kapas and Dean W. Brown and Paula M Farthing and Eleni Hagi-Pavli},
  journal={FEBS letters},
  volume={418 3},
The effects of the novel vasoactive regulatory peptide, adrenomedullin, on human oral keratinocytes was investigated. Adrenomedullin, acting via its specific receptor, stimulated a dose-dependent increase in DNA synthesis, and, in addition, stimulated further changes in the cell cycle resulting in the proliferation of keratinocytes. When cells were incubated in the presence of increasing concentrations of adrenomedullin, there was a rapid and dose-dependent rise in intracellular cyclic AMP… CONTINUE READING


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