Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion.

@article{Kato2003AdrenomedullinGD,
  title={Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion.},
  author={Kazuo Kato and Hang Yin and Jun Agata and Hideaki Yoshida and Lee Chao and Julie Chao},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 4},
  pages={H1506-14}
}
Adrenomedullin (AM) has been shown to protect against cardiac remodeling. In this study, we investigated the potential role of AM in myocardial ischemia-reperfusion (I/R) injury through adenovirus-mediated gene delivery. One week after AM gene delivery, rats were subjected to 30-min coronary occlusion, followed by 2-h reperfusion. AM gene transfer significantly reduced the ratio of infarct size to ischemic area at risk and the occurrence of sustained ventricular fibrillation compared with… CONTINUE READING