Adrenomedullin enhances baroreceptor reflex response via cAMP/PKA signaling in nucleus tractus solitarii of rats.

@article{Ho2008AdrenomedullinEB,
  title={Adrenomedullin enhances baroreceptor reflex response via cAMP/PKA signaling in nucleus tractus solitarii of rats.},
  author={L K Ho and Kevin Chen and I-C Ho and Y-C Shen and David HT Yen and Faith C. H. Li and Young C. Lin and W-K Kuo and Yi Jia Lou and J. C. H. Yen},
  journal={Neuropharmacology},
  year={2008},
  volume={55 5},
  pages={729-36}
}
Adrenomedullin (ADM), a 52-amino acid peptide, elicits differential cardiovascular responses when it is administered systemically or directly to the brain. We evaluated in the present study the hypothesis that ADM may modulate baroreceptor reflex (BRR) response through an ADM receptor-mediated cAMP/ protein kinase A (PKA)-dependent mechanism in the nucleus tractus solitarii (NTS), the terminal site for primary baroreceptor afferents, using Sprague-Dawley rats. Our immunoblot and… CONTINUE READING