Adrenomedullin augments collateral development in response to acute ischemia.

@article{Abe2003AdrenomedullinAC,
  title={Adrenomedullin augments collateral development in response to acute ischemia.},
  author={Minami Abe and Masataka Sata and Hiroaki Nishimatsu and Daisuke Nagata and Etsu Suzuki and Yasuo Terauchi and Takashi Kadowaki and Naoto Minamino and Kenji Kangawa and Hisayuki Matsuo and Yasunobu Hirata and Ryozo Nagai},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={306 1},
  pages={
          10-5
        }
}
Expression of adrenomedullin, discovered as a vasodilatory peptide, is markedly up-regulated under pathological conditions such as tissue ischemia and inflammation, which are associated with neovascularization. Here, we tested the hypothesis that overly expressed adrenomedullin may augment collateral flow to ischemic tissues. We induced hindlimb ischemia in wild-type mice and injected a naked plasmid expressing human adrenomedullin or an empty vector into the ischemic muscle, followed by in… CONTINUE READING

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