Adrenomedullin as a therapeutic target in angiogenesis.

@article{Deville2010AdrenomedullinAA,
  title={Adrenomedullin as a therapeutic target in angiogenesis.},
  author={J L Deville and S{\'e}bastien Salas and Dominique F. Figarella-Branger and L'houcine Ouafik and Laurent Daniel},
  journal={Expert opinion on therapeutic targets},
  year={2010},
  volume={14 10},
  pages={1059-72}
}
IMPORTANCE OF THE FIELD Hypoxia, a frequent characteristic in the microenvironment of solid tumors, leads to adrenomedullin (AM) upregulation through the hypoxia inducible factor-1 pathway, explaining its high expression in a variety of malignant tissues. AM is believed to play an important role in tumor progression and angiogenesis in many cancers. Therefore, it could become a new therapeutic target. AREAS COVERED IN THIS REVIEW We performed a review of the literature based on published data… CONTINUE READING

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