Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: evidences of upregulation of ADM system in immature glands.

Abstract

Evidence has been provided that adrenomedullin (ADM) stimulates the proliferative activity of adult rat adrenal zona glomerulosa (ZG). However, the selective ADM receptor antagonist ADM(22-52), although being able to block ADM effect, was per se ineffective. In contrast, in the companion paper, we showed that ADM(22-52) depresses the proliferation rate of… (More)

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