Adrenomedullin and endothelial barrier function.

  title={Adrenomedullin and endothelial barrier function.},
  author={Bettina Temmesfeld-Wollbrueck and Andreas Hocke and Norbert Suttorp and Stefan Hippenstiel},
  journal={Thrombosis and haemostasis},
  volume={98 5},
Although loss of endothelial barrier function is a hallmark of every acute inflammation and contributes to fatal loss of organ function during severe infections, there is no sufficient therapy for stabilization of endothelial barrier function. Endogenous peptide adrenomedullin (AM) serum levels were shown to be increased during severe infection including sepsis and septic shock. In different in-vitro and in-vivo models AM acted as a potent therapeutic endothelial barrier function-stabilizing… CONTINUE READING


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