Adrenomedullin and adrenomedullin binding protein-1 prevent acute lung injury after gut ischemia-reperfusion.

@article{Dwivedi2007AdrenomedullinAA,
  title={Adrenomedullin and adrenomedullin binding protein-1 prevent acute lung injury after gut ischemia-reperfusion.},
  author={Amit J. Dwivedi and Rongqian Wu and Eric Nguyen and Shinya Higuchi and Haichao Wang and Kambhampaty V. Krishnasastry and Corrado Paolo Marini and Thanjavur S. Ravikumar and Ping Wang},
  journal={Journal of the American College of Surgeons},
  year={2007},
  volume={205 2},
  pages={
          284-93
        }
}
BACKGROUND Ischemic bowel remains a critical problem, resulting in up to 80% mortality. Acute lung injury, a common complication after intestinal ischemia/reperfusion (I/R), might be responsible for such a high mortality rate. Our previous studies have shown that administration of a novel vasoactive peptide adrenomedullin (AM) and its binding protein (AMBP-1) reduces the systemic inflammatory response in rat models of both hemorrhage and sepsis. It remains unknown whether administration of AM… CONTINUE READING
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