Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes.

@article{Tsuruda1998AdrenomedullinAP,
  title={Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes.},
  author={Toshihiro Tsuruda and Junzo Kato and Kazuo Kitamura and Kenji Kuwasako and Tomohiko Imamura and Yasushi Koiwaya and Teppei Tsuji and Kenji Kangawa and Tanenao Eto},
  journal={Hypertension},
  year={1998},
  volume={31 1 Pt 2},
  pages={
          505-10
        }
}
Adrenomedullin (AM), a potent vasodilator peptide, exists in the cardiac ventricle; however, the role of AM in the ventricular tissue remains unknown. In the present study, we investigated the production and secretion of AM in cultured neonatal rat cardiomyocytes, and we examined the effect of AM on de novo protein synthesis in these cells by measuring [14C]phenylalanine incorporation. The cardiomyocytes cultured with serum-free media secreted AM into the media in a time-dependent manner at the… CONTINUE READING

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ADRENOMEDULLIN AND NATRIURETIC PEPTIDES IN CARDIAC HYPERTROPHY

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Adrenomedullin: a possible autocrine or paracrine hormone in the cardiac ventricles.

  • Hypertension research : official journal of the Japanese Society of Hypertension
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Adrenomedullin: Continuing to explore cardioprotection

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