Adrenocorticotropin induction of stress-activated protein kinase in the adrenal cortex in vivo.

@article{Watanabe1997AdrenocorticotropinIO,
  title={Adrenocorticotropin induction of stress-activated protein kinase in the adrenal cortex in vivo.},
  author={Genichi Watanabe and Pedro De La Pe{\~n}a and C. Albanese and Lisa D. Wilsbacher and J. Buchanan Young and Richard G. Pestell},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 32},
  pages={20063-9}
}
A broad array of stressors induce ACTH release from the anterior pituitary, with consequent stimulation of the adrenal cortex and release of glucocorticoids critical for survival of the animal. ACTH stimulates adrenocortical gene expression in vivo and inhibits adrenocortical cell proliferation. Binding of ACTH to its G-protein-coupled receptor stimulates the production of cAMP and activation of the protein kinase A pathway. The stress-activated protein kinases (SAPKs) (or c-Jun N-terminal… CONTINUE READING

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Proliferative signaling initiated in ACTH receptors.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2000
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