Adrenocorticotropin and cortisol responses to a naloxone challenge and risk of alcoholism.

@article{Hernndezvila2002AdrenocorticotropinAC,
  title={Adrenocorticotropin and cortisol responses to a naloxone challenge and risk of alcoholism.},
  author={Carlos A. Hern{\'a}ndez-{\'A}vila and Cheryl A. Oncken and Jeffrey Van Kirk and Gary Wand and Henry R. Kranzler},
  journal={Biological psychiatry},
  year={2002},
  volume={51 8},
  pages={652-8}
}
BACKGROUND Because abnormalities in opioid neurotransmission appear to underlie some of the inherited risk for alcoholism, we examined the effects of naloxone, an opioid antagonist, on corticotropin and cortisol responses in nonalcoholic subjects differentiated by paternal history of alcoholism. METHODS Placebo-controlled, balanced, within-subject design involving 2 test days over a period of 3 to 7 days. Thirty-six subjects (67% male; 53% paternal-history-positive; mean age = 25.0 years… CONTINUE READING

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