Adrenocortical suppression in workers manufacturing synthetic glucocorticoids.

  title={Adrenocortical suppression in workers manufacturing synthetic glucocorticoids.},
  author={Daniel C. Anderson},
  journal={British medical journal},
  volume={1 6105},
A man who had worked for 16 years in the manufacture of a potent corticosteroid was found to be suffering from chronic adrenocortical insufficiency attributed to chronic absorption of the glucocorticoid. Eleven other symptom-free workers were therefore screened. Two of these workers, like the first patient, gave grossly abnormal responses to the Synacthen (tetracosactrin) test; one had been employed for only seven months. All 12 men had facial plethora, suggesting absorption of the drug in… CONTINUE READING