Adrenocortical status predicts the degree of age-related deficits in prefrontal structural plasticity and working memory.

Abstract

Cognitive decline in aging is marked by considerable variability, with some individuals experiencing significant impairments and others retaining intact functioning. Whereas previous studies have linked elevated hypothalamo-pituitary-adrenal (HPA) axis activity with impaired hippocampal function during aging, the idea has languished regarding whether such… (More)
DOI: 10.1523/JNEUROSCI.1385-14.2014

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