Adrenocortical, Autonomic, and Inflammatory Causes of the Metabolic Syndrome: Nested Case-Control Study

@article{Brunner2002AdrenocorticalAA,
  title={Adrenocortical, Autonomic, and Inflammatory Causes of the Metabolic Syndrome: Nested Case-Control Study},
  author={Eric J. Brunner and Harry Hemingway and Brian R. Walker and Michael Page and P Clarke and M. Juneja and Martin J. Shipley and Meena Kumari and Ruth Andrew and Jonathan R Seckl and Andrew S. Papadopoulos and Stuart A. Checkley and Ann Rumley and Gordon D. O. Lowe and Stephen A Stansfeld and Michael Marmot},
  journal={Circulation: Journal of the American Heart Association},
  year={2002},
  volume={106},
  pages={2659-2665}
}
Background—The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain the neuroendocrine adaptations that accompany MS. Methods and Results—This was a double-blind case-control study of working men aged 45 to 63 years drawn from the Whitehall II… Expand
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