Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics.

@article{Hieble2000AdrenoceptorSA,
  title={Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics.},
  author={J. Paul Hieble},
  journal={Pharmaceutica acta Helvetiae},
  year={2000},
  volume={74 2-3},
  pages={163-71}
}
The subdivision of alpha adrenoceptors into the alpha 1 and alpha 2 classes was the impetus for the design of the selective alpha 1-adrenoceptor antagonists, which remain useful antihypertensives. alpha 2-Adrenoceptor agonists also have application as antihypertensive drugs, based on their ability to reduce sympathetic outflow. Likewise, subdivision of the beta adrenoceptors has lead to the development of selective beta 1-adrenoceptor antagonists as antihypertensive and selective beta 2… CONTINUE READING